Current Position

• Organ Transplantation and Hepato – Pancerato Biliary Surgeon

Education

2009-2011: Transplant fellowship, Shiraz University of Medical Sciences, Shiraz, Iran;

2000- 2005: Specialty in Surgery, Shiraz University of Medical Sciences, Shiraz, Iran;

1988-1995: Medical Doctor, Esfahan University of Medical Sciences, Esfahan, Iran;

1984-1990: High School, Harati High school, Esfahan, Iran;

1979-1984: Elementary School, Farabi School, Esfahan, Iran.

Personal Activities

2011 up to now: Fellow of Transplant Surgery, Shiraz University of Medical Sciences

2009 -2011: Fellow of Transplant surgery, Shiraz University of Medical Sciences, Shiraz, Iran

2008-2009: General Surgeon, Shahid-Mohamadi Hospital, Hormozgan Medical Sciences, Hormozgan Iran

2006-2008: General Surgeon, Nabiakram hospital, Khong, Shiraz University of Medical Sciences, Iran.

1995-2000: General Practitioner, Fasa health and treatment network, Fasa University of Medical Sciences, Iran.

Membership

Membership in Scientific Societies as fallow:

• Member of the Iranian Medical Council;
• Member of the Iranian Association of General Surgeons;
• Member of the Iranian transplant Association.

Publications

1. Exp Clin Transplant. 2012 Aug; 10(4):307-9.
   Clinical experience in organ transplant from the Shiraz Transplant Center: 2011.
   Nikeghbalian S1, Aliakbarian M, Kazemi K, Shamsaeefar A, Salehipour M, Bahreini A, Mehdi SH, Salahi H, Bahador A, Malekhossein SA.Shiraz University of Medical Sciences, Shiraz, Iran.
2. EXCLI J. 2019 Aug 22; 18:666-676. Doi: 10.17179/excli2019-1698. ECollection 2019.
   Cytoprotective effects of ginsenoside Rd on apoptosis-associated cell death in the isolated human pancreatic islets.
   Kaviani M1, Keshtkar S1,2, Azarpira N1, Hossein Aghdaei M1, Geramizadeh B1, Karimi MH1, Yaghobi R1, Esfandiari E1, Shamsaeefar A3, Nikeghbalian S3, Al-Abdullah IH4.
3. Clin Res Hepatol Gastroenterol. 2019 Oct 11. Pii: S2210-7401(19)30216-5. Doi: 10.1016/j.clinre.2019.09.002.
   Characterization of biopsy proven non-alcoholic fatty liver disease in healthy non-obese and lean population of living liver donors: The impact of uric acid.
   Eshraghian A1, Nikeghbalian S2, Geramizadeh B2, Kazemi K2, Shamsaeefar A2, Malek-Hosseini SA2.
4. Exp Clin Transplant. 2019 Oct 1. Doi: 10.6002/ect.2019.0205.
   Nonalcoholic Steatohepatitis Is the Most Rapidly Growing Indication for Liver Transplantation in Iranian Patients.
   Eshraghian A1, Nikeghbalian S, Dehghani M, Shamsaeefar A, Kazemi K, Nikoopour H, Eghlimi H, Gholami S, Salahi H, Malek-Hosseini SA.
5. Int J Organ Transplant Med. 2019; 10(3):108-113.
   The Effects of Cold Preservation Solutions Supplemented with UDCA and α-Lipoic Acid on the Viability and Function of Isolated Human Hepatocytes.
   Hossein Aghdaie M1, Azarpira N1, Esfandiari E1, Kaviani M1, Golbabapour S1, Shamsaeefar A2, Kazemi K2, Dehghani M2, Bahador A2, Salahi H2, Nikeghbalian S2, Malek-Hosseini SA2, Geramizadeh B1,3.
6. HPB (Oxford). 2019 Aug 17. Pii: S1365-182X (19)30634-3. Doi: 10.1016/j.hpb.2019.07.015.
   Non-alcoholic fatty liver disease after liver transplantation in patients with non-alcoholic steatohepatitis and cryptogenic cirrhosis: the impact of pre-transplant graft Steatosis.
   Eshraghian A1, Nikeghbalian S2, Kazemi K2, Shamsaeefar A2, Geramizadeh B2, Malek-Hosseini SA2.
7. Sci Rep. 2019 Aug 12; 9(1):11701. Doi: 10.1038/s41598-019-48262-6.
   Protective effect of nobiletin on isolated human islets survival and function against hypoxia and oxidative stress-induced apoptosis.
   Keshtkar S1, Kaviani M2, Jabbarpour Z1, Geramizadeh B2, Motevaseli E1, Nikeghbalian S3, Shamsaeefar A3, Motazedian N2, Al-Abdullah IH4, Ghahremani MH5,6, Azarpira N7,8.
8. Exp Clin Transplant. 2019 Jul 2. Doi: 10.6002/ect.2019.0089.
   Hepatic Computed Tomography Volumetry for Noninvasive Detection of Hepatic Steatosis and Steatohepatitis in Living Liver Donors.
   Eshraghian A1, Rasekhi A, Nikeghbalian S, Muhammad S, Kazemi K, Jalaeian H, Shamsaeefar A, Geramizadeh B, Malek-Hosseini SA.
9. Eur J Pharmacol. 2019 Sep 5; 858:172518. Doi: 10.1016/j.ejphar.2019.172518. Epub 2019 Jun 29.
   Amelioration of the apoptosis-mediated death in isolated human pancreatic islets by minocycline.
   Kaviani M1, Keshtkar S2, Azarpira N3, Aghdaei MH1, Geramizadeh B1, Karimi MH1, Shamsaeefar A4, Motazedian N1, Nikeghbalian S4, Al-Abdullah IH5.
10. J Gastrointest Cancer. 2019 Apr 27. Doi: 10.1007/s12029-019-00244-7.
    Liver Transplantation for High-Grade Primary Hepatic Neuroendocrine Tumor with Diffuse Liver Metastasis.
    Nikeghbalian S1, Eshraghian A2, Kazemi K1, Shamsaeefar A1, Hosseinzadeh M3, Geramizadeh B3, Malek-Hosseini SA1.
11. Biomed Pharmacother. 2019 Apr; 112:108674. Doi: 10.1016/j.biopha.2019.108674. Epub 2019 Feb 19.
    Cytoprotective effects of olesoxime on isolated human pancreatic islets in order to attenuate apoptotic pathway.
    Kaviani M1, Keshtkar S2, Azarpira N3, Aghdaei MH1, Geramizadeh B1, Karimi MH1, Shamsaeefar A4, Motazedian N1, Nikeghbalian S4, Al-Abdullah IH5, Ghahremani MH6.
12. Int J Clin Pract. 2018 Dec 28:e13309. Doi: 10.1111/ijcp.13309.
    Portal vein thrombosis in patients with liver cirrhosis and its impact on early and long-term outcomes after liver transplantation.
    Eshraghian A1, Nikeghbalian S1, Kazemi K1, Mansoorian M1, Shamsaeefar A1, Eghlimi H1, Gholami S1, Salahi H1, Malek-Hosseini SA1.
13. Arch Iran Med. 2018 Jul 1; 21(7):275-282.
    Liver Transplantation Status in Iran: A Multi-center Report on the Main Transplant Indicators and Survival Rates.
    Malek-Hosseini SA1, Jafarian A2, Nikeghbalian S1, Poustchi H3, Lankarani KB1, Nasiri Toosi M2, Salahi H1, Dehghani M1, Eshraghian A1, Sharafkhah M3, Eghtesad S3, Motamed-Gorji N3, Kazemi K1, Salimi J2, Moini M2, Shamsaeefar A1, Moini M1, Dehghani M4, B Khosravi M1, Najafi A2, Sattari H4, Geramizadeh B1, Shafiee M4, Toutouni MN5, Sanei B6, Nejatollahi SM7, Taghavi A1, Bahador A1, Aliakbarian M5, Eghtesad B8, Malekzadeh R3.
14. Exp Clin Transplant. 2018 Jul 11. Doi: 10.6002/ect.2017.0246.
    Retransplant of the Liver: 12-Year Experience of the Shiraz Organs Transplantation Center.
    Shamsaeefar A1, Saleh T, Kazemi K, Nikeghbalian S, Dehghani M, Mansurian M, Gholami S, Khosravi B, Malek Hosseini SA.
15. Exp Clin Transplant. 2018 Apr 20. Doi: 10.6002/ect.2017.0110.
    Single Center Long-Term Results of Pediatric Liver Transplantation.
    Al Sayyed MH1, Shamsaeefar A, Nikeghbalian S, Dehghani SM, Bahador A, Dehghani M, Rasekh R, Gholami S, Khosravi B, Malek Hosseini SA.
16. Clin Transplant. 2018 May; 32(5):e13241. Doi: 10.1111/ctr.13241. Epub 2018 Apr 6.
    University of Wisconsin vs normal saline solutions for preservation of blood vessels of brain dead donors: A histopathological study.
    Kazemi K1, Nikeghbalian Z1, Yaghmaei S2, Nikeghbalian S1, Shamsaeefar A1, Asgharnia Y3, Dehghankhalili M4, Golchini A2, Malekhosseini SA1
17. Prog Transplant. 2017 Jun; 27(2):192-195. Doi: 10.1177/1526924817699964. Epub 2017 Mar 22.
    Thirteen-Year Evaluation of the Management of Biliary Tract Complication after Deceased Donor Liver Transplantation.
    Shamsaeefar A1, Nikeghbalian S1, Kazemi K1, Motazedian N2, Geramizadeh B2, Malekhosseini SA1.
18. Exp Clin Transplant. 2019 Apr; 17(2):263-265. Doi: 10.6002/ect.2016.0158. Epub 2017 Apr 14.
    Kidney Transplant from a Deceased Donor with Renal Artery Aneurysm: A Case Report.
    Shamsaeefar A1, Nikeghbalian S, Kazemi K, Mansorian M, Motazedian N, Malekhosseini SA.
19. Clin Transplant. 2017 Jun; 31(6). Doi: 10.1111/ctr.12964. Epub 2017 Apr 19.
    Biliary reconstruction in liver transplant patients with primary sclerosing cholangitis, duct-to-duct or Roux-en-Y?
    Shamsaeefar A1, Shafiee M1, Nikeghbalian S1, Kazemi K1, Mansorian M1, Motazedian N2, Afshinnia F3, Geramizadeh B2, Malekhosseini SA1.
20. World J Gastroenterol. 2017 Feb 21; 23(7):1224-1232. Doi: 10.3748/wjg.v23.i7.1224.
    Post-transplant lymphoproliferative disorder after liver transplantation: Incidence, long-term survival and impact of serum tacrolimus level.
    Eshraghian A1, Imanieh MH1, Dehghani SM1, Nikeghbalian S1, Shamsaeefar A1, Barshans F1, Kazemi K1, Geramizadeh B1, Malek-Hosseini SA1.
21. Exp Clin Transplant. 2017 Feb; 15(Suppl 1):269-272.
    Impact of a Full-Time Donor Management Protocol on Donors’ Liver Biopsy Findings: Progress to Date.
    Mojtabaee M1, Shamsaeefar A, Gholami S, Mohsenzadeh M, Sadegh Beigee F.
22. Exp Clin Transplant. 2018 Apr; 16(2):177-181. Doi: 10.6002/ect.2016.0129. Epub 2017 Feb 7.
    Experience of Liver Transplant in Patients Diagnosed with Budd-Chiari Syndrome.
    Raza SM1, Zainab S, Shamsaeefar AR, Nikeghbalian S, Malek Hosseini SA.
23. Hepat Mon. 2016 Oct 8; 16(10):e40140. ECollection 2016 Oct.
    Transplantation of Deceased Donor Livers with Elevated Levels of Serum Transaminases at Shiraz Transplant Center.
    Fakhar N1, Nikeghbalian S1, Kazemi K1, Shamsayeefar AR1, Gholami S1, Kasraianfard A2, Malek-Hosseini SA1.
24. Exp Clin Transplant. 2019 Feb; 17(1):119-120. Doi: 10.6002/ect.2016.0052. Epub 2016 Jul 22.
    Curative Treatment of Ornithine Transcarbamylase Deficiency with a Liver Transplant: A Case Report.
    Shamsaeefar A1, Nikeghbalian S, Dehghani SM, Kazemi K, Motazedian N, Geramizadeh B, Malekhosseini SA.
25. Saudi J Kidney Dis Transpl. 2016 Jul-Aug; 27(4):665-70. Doi: 10.4103/1319-2442.185221.
    Effects of induction therapy with alemtuzumab versus antithymocyte globulin among highly sensitized kidney transplant candidates.
    Shamsaeefar A1, Roozbeh J2, Khajerezae S1, Nikeghbalian S1, Kazemi K1, Motazedian N3, Geramizadeh B3, Malekhosseini SA1.
26. Pediatr Transplant. 2015 Sep; 19(6):605-11. Doi: 10.1111/petr.12562.
    Liver transplantation as a definitive treatment for familial hypercholesterolemia: A series of 36 cases.
    Mansoorian M1, Kazemi K1, Nikeghbalian S1, Shamsaeefar A1, Mokhtari M2, Dehghani SM3, Bahador A1, Salahi H1, Amoozgar H4, Malek Hosseini SA1.
27. Liver Transpl. 2015 May; 21(5):696-9. Doi: 10.1002/lt.24095.
    Liver transplantation and Whipple surgery combined with chemoradiotherapy for treatment of hilar cholangiocarcinoma in patients with primary sclerosing cholangitis.
    Nikeghbalian S1, Shamsaeefar A, Eshraghian A, Mansoorian MR, Kazemi K, Geramizadeh B, Malek-Hosseini SA.
28. Exp Clin Transplant. 2015 Oct; 13(5):426-9. Doi: 10.6002/ect.2013.0193. Epub 2014 Sep 17.
    Prevention of Post-transplant Lymphoproliferative Disorder in Pediatric Patients with a Liver Transplant.
    Aliakbarian M1, Dehghani SM, Geramizadeh B, Nikeghbalian S, Kasiri K, Kazemi K, Shamsaeefar A, Bahador A, Malekhosseini SA.
29. Arch Iran Med. 2014 Sep; 17(9):640-1. Doi: 0141709/AIM.0012.
    En-bloc liver-pancreas transplant in Iran.
    Nikeghbalian S1, Mehdi SH2, Aliakbarian M3, Kazemi K2, Shamsaeefar A2, Bahreini A2, Gholami S2, Malekhosseini SA3.
30. Int J Organ Transplant Med. 2014; 5(3):120-4.
    Ex-vivo Resection and Small-Bowel Auto-transplantation for the Treatment of Tumors at the Root of the Mesentery.
    Nikeghbalian S1, Aliakbarian M2, Kazemi K1, Shamsaeefar AR1, Mehdi SH1, Bahreini A1, Malek-Hosseini SA1.
31. Int J Organ Transplant Med. 2014; 5(2):59-65.
    Multivisceral and small bowel transplantation at Shiraz organ transplant center.
    Nikeghbalian S1, Mehdi SH1, Aliakbarian M2, Kazemi K1, Shamsaeefar A1, Bahreini A1, Mansoorian MR1, Malekhosseini SA1.
32. Int J Organ Transplant Med. 2014; 5(1):34-7.
    Shiraz guideline for the management of patients with brain death.
    Firoozifar M1, Khosravi MB1, Ghafari S1, Sahmeddini MA1, Eghbal H1, Salahi H1, Bahador A1, Nikeghbalian S1, Kazemi K1, Shamsaeefar AR1, Gholami S1, Farhadi E1, Shahnazi MA1, Malek-Hosseini SA1.
33. Exp Clin Transplant. 2016 Feb; 14(1):93-5. Doi: 10.6002/ect.2013.0260. Epub 2014 Jun 9.
    Nutcrackerlike Phenomenon Is An Unusual Cause for Gross Hematuria After a Kidney Graft.
    Salehipour M1, Kazemi K, Shamsaeefar A, Hekmati P, Sanaei AK, Bahador A, Aliakbarian M, Malek Hosseini SA.
34. Exp Clin Transplant. 2016 Apr; 14(2):235-7. Doi: 10.6002/ect.2013.0277. Epub 2014 Jun 9.
    Modified Multivisceral Transplant After Acute Abdominal Trauma.
    Nikeghbalian S1, Alaa Eldin A, Aliakbarian M, Kazemi K, Shamsaeefar A, Gholami S, Malekhosseini SA.
35. Exp Clin Transplant. 2015 Apr;13(2):163-6. doi: 10.6002/ect.2013.0135. Epub 2014 May 19.
    De novo malignancy after liver transplant.
    Sanaei AK1, Aliakbarian M, Kazemi K, Nikeghbalian S, Shamsaeefar A, Mehdi SH, Bahreini A, Dehghani SM, Geramizadeh B, Malekhosseini SA.
36. Exp Clin Transplant. 2014 Mar; 12 Suppl 1:178-81.
    Discarded organs at Shiraz Transplant Center.
    Shamsaeefar A1, Nikeghbalian S, Kazemi K, Mansorian M, Gholami S, Motazedian N, Malekhosseini SA.
37. Transplant Proc. 2013; 45(10):3528-30. Doi: 10.1016/j.transproceed.2013.09.002.
    Multivisceral transplantation for the treatment of intra-abdominal tumors.
    Nikeghbalian S1, Aliakbarian M, Shamsaeefar A, Kazemi K, Bahreini A, Malekhosseini SA.
38. Arch Iran Med. 2013 Jun; 16(6):348-50. Doi: 013166/AIM.008.
    Hepatocellular carcinoma in explanted livers of patients with genotype d HBV cirrhosis: report of the first experience from Iran.
    Geramizadeh B1, Nikeghbalian S, Kazemi K, Shamsaifar A, Bahador A, Salahi H, Malekhosseini SA, Kashtkar Jahromi M, Bakhshai Dehkordi A.
39. Exp Clin Transplant. 2012 Aug; 10(4):307-9.
    Clinical experience in organ transplant from the Shiraz Transplant Center: 2011.
    Nikeghbalian S1, Aliakbarian M, Kazemi K, Shamsaee far A, Salehipour M, Bahreini A, Mehdi SH, Salahi H, Bahador A, Malekhossein SA.
40. Int J Organ Transplant Med. 2012; 3(3):111-4.
    En-bloc Transplantation: an Eligible Technique for Unilateral Dual Kidney Transplantation.
    Salehipour M1, Bahador A1, Nikeghbalian S1, Kazemi K1, Shamsaeifar AR1, Ghaffaripour S1, Sahmeddini MA1, Salahi H1, Bahreini A1, Janghorban P1, Gholami S1, Malek-Hosseini SA1.
41. Int J Organ Transplant Med. 2010; 1(4):189-92.
    The first modified Multivisceral transplantation in the Middle East: a major advance in transplantation surgery in Shiraz transplant center.
    Nikeghalian S1, Davari HR1, Kakaei F1, Shamsaeefar A1, Sanei B1, Geramizadeh B1, Moini M1, Sahmeddini MA1, Malek-Hosseini SA1.
42. Int J Organ Transplant Med. 2010; 1(1):44-8. Epub 2010 Feb 1.
    Liver transplantation in the presence of old portal vein thrombosis.
    Kakaei F1, Nikeghbalian S1, Salahi H1, Bahador A1, Kazemi K1, Dehghani M1, Shamsaeefar A1, Sanei B1, Ghaffaripour S1, Rajaei E1, Gholami S1, Malek-Hosseini SA1.
43. Transplant Proc. 2009 Sep; 41(7):2939-41. Doi: 10.1016/j.transproceed.2009.07.028.
    Liver transplantation for homozygous familial hypercholesterolemia: two case reports.
    Kakaei F1, Nikeghbalian S, Kazemi K, Salahi H, Bahador A, Dehghani SM, Dehghani M, Nejatollahi SM, Shamsaeefar A, Khosravi MB, Malek-Hosseini SA.
44. Transplant Proc. 2009 Sep; 41(7):2729-30. Doi: 10.1016/j.transproceed.2009.07.029.
    Transperitoneal laparoscopic living donor nephrectomy: 2 years’ experience.
    Nikeghbalian S1, Kazemi K, Salehipour M, Roozbeh J, Sagheb MM, Kakaei F, Dehghani M, Shamsaeefar A, Ghaffaripour S, Banihashemi SJ, Malek-Hosseini SA.
45. Liver transplantation for homozygous familial hypercholesterolemia: two case reports
    …, M Dehghani, SM Nejatollahi, A Shamsaeefar… – Transplantation …, 2009 – Elsevier
    Homozygous familial hypercholesterolemia (HFHC) is a rare inherited condition with an
    incidence of one in one million. It is associated with severe premature atherosclerosis and
    early death from cardiovascular complications. Mutation in the gene that encodes the …
46. Liver transplantation as a definitive treatment for familial hypercholesterolemia: a series of 36 cases
    …, S Nikeghbalian, A Shamsaeefar… – Pediatric …, 2015 – Wiley Online Library
    FH is a genetic disorder characterized by an increase in serum LDL and total cholesterol
    values. The afflicted patients are at increased risk of premature atherosclerosis and
    myocardial infarction. Different treatment modalities are present, including pharmacological …
47. Multivisceral transplantation for the treatment of intra-abdominal tumors
    S Nikeghbalian, M Aliakbarian, A Shamsaeefar… – Transplantation …, 2013 – Elsevier
    Background some intra-abdominal or retroperitoneal tumors such as low-grade slow-
    growing malignancies may seem unrespectable due to major vessel encasement or presence
    of intra-abdominal dissemination, but the slow growth rate and to some extent long life …
48. Post-transplant lymphoproliferative disorder after liver transplantation: Incidence, long-term survival and impact of serum tacrolimus level
    …, S Nikeghbalian, A Shamsaeefar… – World journal of …, 2017 – ncbi.nlm.nih.gov
    21` METHODS A cross-sectional survey was
    cond ucted among patients who underwent liver transplantation at Shiraz Transplant Center …
49. Ex-vivo resection and small-bowel auto-transplantation for the treatment of tumors at the root of the mesentery
    …, K Kazemi, AR Shamsaeefar… – … journal of organ …, 2014 – ncbi.nlm.nih.gov
    Background: Tumors involving the root of the mesentery are generally regarded as
    “unresectable” with conventional surgical techniques. Resection with conventional surgery
    may end in life-threatening complications in these patients. Ex-vivo resection and auto …
50. Transperitoneal laparoscopic living donor nephrectomy: 2 years’ experience
    …, F Kakaei, M Dehghani, A Shamsaeefar… – Transplantation …, 2009 – Elsevier
    Background Due to the shortage of organ donations and the rising number of patients with
    terminal renal insufficiency, living donor kidney donation has become increasingly important
    during recent years. Hand-assisted laparoscopic living donor nephrectomy (LLDN) is an …
51. De novo malignancy after liver transplant
    …, K Kazemi, S Nikeghbalian, A Shamsaeefar… – Exp Clin …, 2015 – researchgate.net
    Objectives: Patients who have liver transplant are at high risk of developing de novo
    malignancies. The purpose of this study was to evaluate incidence and histologic type of de
    novo malignancies after liver transplant in a liver transplant center. Materials and Methods …
52. Liver transplantation and whipple surgery combined with chemoradiotherapy for treatment of hilar cholangiocarcinoma in patients with primary sclerosing …
    S Nikeghbalian, A Shamsaeefar… – Liver …, 2015 – Wiley Online Library
    DISCUSSION Herein, we describe 4 PSC patients with hilar CC treated with OLT–Whipple
    surgery combined with chemoradiotherapy. Patients with confirmed hilar CC were explored
    for regional and distant metastasis before OLT. One of our patients remained tumor-free for 3 …
53. Bowel perforation by crumpled paper in a patient presenting with acute abdominal pain
    …, SMV Hosseini, T Razmi, A Shamsaeefar – Saudi journal of …, 2009 – ncbi.nlm.nih.gov
    Many of the abdominal foreign bodies are due to accidental ingestion. Our objective in this
    case report is to emphasize the importance of the enquiry about the foreign body in the
    differential diagnosis of acute abdominal pain. According to our knowledge, this is the first …
54. Cholangiocarcinoma Secondary to Primary Sclerosing Cholangitis in Explanted Livers: A Single-Center Study in the South of Iran
    …, R Ghavvas, K Kazemi, A Shamsaeefar… – Hepatitis …, 2015 – ncbi.nlm.nih.gov
    Background: Primary sclerosing cholangitis (PSC) is a chronic disease, characterized by
    chronic inflammation and fibrosis of bile duct epithelial cells. This is a significant contributory
    factor to the development of malignancy, most commonly cholangiocarcinoma (CCA), which …